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angleščina

However, "de novo" resistance to endocrine therapy undermines the efficacy of using competitive inhibitors like tamoxifen. en.wikipedia.org

This effect may have therapeutical relevance given that the schistosome, as the taenia and the echinococcus (other praziquantel sensitive parasites), is unable to synthesize purines such as adenosine "de novo". en.wikipedia.org

After fusion, the cells are grown in a medium with methotrexate or aminopterin that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate. en.wikipedia.org

This gene encodes an enzyme - dihydroorotate dehydrogenase - which catalyses the ubiquinone-mediated oxidation of dihydroorotate to orotate, the fourth enzymatic step in "de novo" pyrimidine biosynthesis. en.wikipedia.org

Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin. en.wikipedia.org

Aminopterin in the medium blocks the de novo pathway. en.wikipedia.org

Bacterial abscesses rarely (if ever) arise "de novo" within the brain, although establishing a cause can be difficult in many cases. en.wikipedia.org

A claim that there was no legal basis for the action called for "de novo" review, and the panel proceeded from there. en.wikipedia.org

These compounds can be formed by "de novo" synthesis or by modifying a pre-existing pyrrolizidine alkaloid that is consumed from the plant. en.wikipedia.org

The court concluded that... if we were called upon to review the guardianship court's decision "de novo," we would still affirm it. en.wikipedia.org

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